Exploring Electrohydrodynamics based Functional Nanofibers as Three-dimensional Nano-Biointerfaces

Session

Poster Session Two

Authors

Associate Professor Menglin Chen (1)

Affiliations

1. Aarhus University

Keywords

Electrohydrodynamics, nanofibrous biomaterials, electrical stimulation, neural tissue engineering, cardiac tissue engineering

Abstract text

The significance of the overall fibrillar and porous nanoscale topography of the extracellular matrix in promoting essential cellular processes has led to consideration of biomaterials with nanofibrous features. Of the many methods for fabricating fibers with micrometer and nanometer diameters, electrospinning is simplest, most straightforward and cost-effective. Fibers are produced by forcing a polymer melt or solution through a spinneret in the presence of a high electric field. This approach becomes intriguingly powerful when remarkable morphological features are combined with unique chemical, physical, or mechanical functionalisation by adding desired components with ease and control. Our current research focuses on exploring new possibilities to fabricate three-dimensional nano-biointerfaces that synergise the nanostructural induction and the bioelectrical/biochemical signalling to affect cellular behaviours, for biomedical applications in neural, bone, muscle tissue engineering and cancer modeling.(1-7)

References

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"Bionic Opto-responsive Fiber for Directing Neurite Growth"

Materials Today Nano, 100311

2 Su, Y; Müller, C; Xiong, X; Dong, M; Chen, M*.

“Reshapable Osteogenic Biomaterials Combining Flexible Melt Electrowritten Organic Fibers with Inorganic Bioceramics”

Nano Letters 2022, 22, 3583 (IF 12.26)

2 Amagat, J; Y Su, Y; Svejsø, FH; Friec, A Le; Sønderskov, SM; Dong, M; Fang,Y; Chen, M*

“Self-snapping hydrogel-based electroactive microchannels as nerve guidance conduits”

Materials Today Bio 2022 16, 100437 (IF 10.16)

3.     Su, Y; Qiu, T; Song, W; Han, X; Sun, M; Wang, Z; Xie, H; Dong, MD; Chen, M*.

“Melt Electrospinning Writing of Magnetic Microrobots.”

Advanced Science, 2021, 2003177. (IF 17.52)

4.      Su, Yingchun; Toftdal, Mette Steen; Friec, Alice Le; Dong, MD; Han, Xiaojun; Chen, Menglin*.

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration. 

Small Science, 2021. 1(7) 210003

5. Zhang, Z; Jørgensen, ML; Wang Z; Amagat J; Wang Y; Li Q; Dong MD; Chen, M*

“3D anisotropic photocatalytic architectures as bioactive nerve guidance conduits for peripheral neural regeneration.”, 

Biomaterials, 2020 253, 120108 (IF 15.3)

6. Xu R; Zhang Z; Toftdal M; Møller A.C.; Dagnaes-Hansen, F; Dong, M; Thomsen, JS; Brüeld, A; Chen, M*

“Synchronous Delivery of Hydroxyapatite and Connective Tissue Growth Factor derived Osteoinductive Peptide Enhanced Osteogenesis”

Journal of Controlled Release, 2019, 301, 129 (IF 11.47)

7. Zhang Z; Klausen, LH; Chen, M; Dong, M

“Electroactive Scaffolds for Neurogenesis and Myogenesis: Graphene-based Nanomaterials"

Small 2018, 1801983 (IF 15.15)