Deconstructing the tumour microenvironment in glioblastoma using imaging mass cytometry
- Abstract number
- 304
- DOI
- 10.22443/rms.mmc2023.304
- Corresponding Email
- [email protected]
- Session
- Spatial and Imaging Cytometry
- Authors
- Dr Michael Haley (1), Leoma Bere (1), Prof Kevin Couper (1)
- Affiliations
-
1. University of Manchester
- Keywords
glioblastoma, tumour microenvironment, imaging mass cytometry, high dimensional imaging
- Abstract text
Glioblastoma (GBM) treatment lags behind other cancers primarily because of its cellular and spatial heterogeneity. We do not understand how different neoplastic and immune cell subsets interact, or where their interactions occur in the tumour, or how these interactions affect GBM disease trajectory. Imaging mass cytometry (IMC) is a new technology that allows imaging of 40+ protein markers in tissues, giving new insights into how tissues are spatially organised at the cellular level, and how cells interact in health and disease. We have therefore used IMC in combination with novel bioinformatics approaches to deconstruct the tumour microenvironment and understand how neoplastic and immune cell interact in glioblastoma, and how these interactions may affect disease outcome.